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科研工作 Departments

主要研究方向


2015年04月09日 12:38 

 

主要研究方向:

 

方向一:卫生检验新技术新方法研究

 

主要研究健康相关产品安全检测与评价,及环境介质健康危害的敏感性生物标志物的检测。

 

方向二:预测医学(计算系统生物医学)

 

利用大数据对公共卫生领域影响重大的疾病进行预测模型建立,对肿瘤、心脑血管疾病、呼吸系统疾病等常见多发慢性疾病的预测和预防方案进行研究。

 

方向三:环境重金属污染防治与监测新技术

 

主要内容研究水环境中重金属污染监测和防治和环境空气中重金属监测和防治

 

方向四:重大疾病发病机制及其化学预防

 

主要内容利用分子生物学、细胞生物学、分子病理等手段研究人类重大疾病如肿瘤、心血管、内分泌等疾病发病的分子机制,以及研究天然化合物在重大疾病中的化学预防作用。

 

学科队伍

 

教授3人,副教授2人,讲师2人;其中:博士学位5名;博士导师3名,硕士导师2名。3名教授分别在全国性专业学会担任理事、委员或省级学会担任副主任委员、委员等职务。

 

科研成果

 

主要承担课题:

 

1. 心脏细胞药物作用评价系统的开发, 项目代码50201029, 教育部基本业务费5万元, 2010.1-2012.12, 主持.

 

2. 第一茶叶及烟草中香精高通量筛查及精准鉴证方法,项目代码01410088-03,质检公益性行业科研专项,51万元, 2014.8-2015.12,排第二,主要参加者.

 

3. 飞燕草素通过Nrf2信号通路在癌症化学预防中的作用机制的研究,项目代码81472972,国自,85万元,2015.12018.12,排第二,主要参加者.

 

4湖南省科技计划新型纳米药物载体的制备及应用研究,编号:2011GK3208

 

5湖南省自然科学基金多功能纳米药物载体材料的自组装合成及性能研究, 编号:12JJ5005

 

6湖南省教育厅教改项目预防医学专业实验教学体系改革研究,编号:71201007009

 

7、国家自然科学基金项目复杂体系中微量PTP1B抑制剂的快速识别新方法研究, 编号:21175155

 

8国家自然科学基金项目“CrVI)干扰肝细胞线粒体电子传递链功能的作用机制研究, 编号:30671776

 

9.国家自然科学基金青年基金项目,30801322、从表观遗传学角度探讨鼻咽癌发生的分子机制、2009/01-2011/1220万元、已结题、主持。

 

10.湖南省自然科学基金青年基金项目,10JJ4025DLC-1基因在鼻咽癌中的生物学功能及其分子机制研究、2010/01-2012/122万元、已结题、主持。

 

11.国家自然科学基金面上项目,81472355MSI2 基因在胶质瘤中的功能和作用机制研究、2015/01-2018/1275 万元、在研、参与。

 

12.国家自然科学基金面上项目,81272972Flotillin-2在鼻咽癌中的活化、作用和分子机制研究、2013/01-2016/1270万元、在研、参与。

 

13.国家自然科学基金风险基金项目,81172206、鼻咽癌特异性核酸适配体及蛋白质分子标志物的筛选和鉴定、2012/01-2012/1214万元、已结题、参与。

 

14.国家自然科学基金面上项目,81070993、新基因HESRG调控人胚胎干细胞神经分化的研究、2011/01-2013/1236万元、已结题、参与。

 

15.国家重点基础研究发展计划(973计划),2010CB833605、基于功能表位的高通量抗体筛选及功能研究、2010/01-2014/12100万元、已结题、参与。

 

16.国家自然科学基金面上项目,30871246、人胚胎干细胞特异性高表达HESRG新基因的功能研究、2009/01-2011/1234万元、已结题、参与。

 

17.国家高技术项目(863项目子课题),2007AA021809、纳米药物制剂的生物效应研究,2009/01-2011/1240万、已结题、参与。

 

18.国家高技术项目(863 项目子课题),2007AA0218011、以新生血管为靶标的抗肿瘤给药系统研发,2009/01-2011/1238 万、已结题、参与。

 

 

发表文章:

 

1. 贺晓烨, 刘晓娜, 王建武, 蔺洁. 新疆兵团第十师包虫病流行状况调查. 疾病预防控制通报, 2014, 29(3): 22-26.

 

2. 向鹏程, 王建武, 王晓琳, 邢伟. 浅谈加强ICU护患沟通提高护理满意度. 中国医疗管理科学.2014, 14(3): 280-280.

 

3. 王晓琳, 王建武. 护士绩效考核在某三甲医院重症医学科中的应用.大家健康, 20148(8):4-6.

 

4. 何燕娟, 王建武, 林旗, 孟晓辉. 医院党员思想状况的调查与思考.中南林业科技大学学报(社会科学版),2014, 8(2):146-148.

 

5. 曾艳妮, 王建武. 泌尿造瘘术患者的心理状态分析和护理对策.当代护士2014,3: 137-139

 

6. 陈亚平, 王建武. 超声光散射乳腺成像系统诊断乳腺癌2. 中国保健营养2013, 23(11): 7002-7002.

 

7. 邢伟, 贺晓烨, 王建武, 杨明施. 谷氨酰胺对急性肺损伤大鼠HGF及KGF的影响. 中国现代医学杂志, 2013, 23(10): 28-31.

 

8. 陈隽, 王建武. 临床实习生心理健康状况及影响因素. 实用预防医学, 2012, 19(12):1896-1898.

 

9. Cha CY, Nakamura Y, Himeno Y, Wang J, Fujimoto S,Inagaki N, Earm YE, Noma A. Ionic mechanisms and Ca2+ dynamicsunderlying the glucose response of pancreatic β cells: a simulation study. JGen Physiol., 2011, 138(1):21-37.

 

10. Nakamura Y, Fujimoto S , Wang J,Himeno Y, Cha C, Shimayoshi T , Noma A, Inagaki N .Analysis of membrane potential oscillation mechanism in the novel pancreaticbeta cell simulation model. Diabetologia 52, S176-177, 2009.

 

11.YukikoHimeno, Chae Young Cha, Takao Shimayoshi, Yasuhiko Nakamura, Jian-Wu Wang,Akinori Noma, Nobuya Inagaki. Estimating Contribution of Individual IonicComponents to the Cardiac Pacemaker Potential. Biophysical Journal 96 (3):S259a,2009.

 

12.Jian-WuWang, Kazuto Yazawa, Kaoru Yamaoka, Masaki Kameyama. Effects of heat on L-typeCa2+ currents in cardiac myocytes. J. Physiol. Sci. 57 (Suppl.):S229-S229, 2007.  

 

13. Kazuto Yazawa, Jian-Wu Wang, Li-Ying Hao, YoshioOnoue and Masaki Kameyama. Verrucotoxin modulates ion channels in guinea-pigventricular myocytes. Br. J. Pharmacol. 2007, 151(8): 1198-1203.

 

14. Jian-Wu Wang,Kazuto Yazawa, Li-Ying Hao, Yoshio Onoue, Masaki Kameyama. Verrucotoxininhibits KATP channels in cardiac myocytes through a muscarinic M3 receptor-PKCpathway. Euro. J. Pharmacol. 2007, 563(1-3): 172-179.

 

15. Jian-Wu Wang, Yuan-Jing Yu, Fumio Hashimoto, YusukeSakata, Makoto Fujii and De-Xing Hou. Baicalein induces apoptosis throughROS-mediated mitochondrial dysfunction pathway in HL-60 cells. Int. J. Mol.Med. 2004, 14(4): 627-32.

 

16. 王建武,陈孝珊,贺建华. 桐粕中醇溶性毒素分离纯化及其性质. 湖南农业大学学报(自然科学版)2002, 28(5)425-428.

 

17.Cuimei Chen, Guiyin Li, Ping Ding. Evaluation of in vivo-in vitrorelease of

 

theophylline from novel controlled releasemicrospheres.International Journal ofPharmacy and Pharmaceutical Sciences.2014, 6:551-555.

 

18.Ruixue Huang, PingDing, Dequn Huang, Fei Yang. Antibiotic pollution threatens public health inChina. Lancet, 2015, 385: 773-774

 

19.Yong Huang, ZhideZhou, Jintao Liang, Ping Ding, Liangli Cao,Zhencheng Chen,

 

20.Guiyin Li.Preparation, characterisation and in vitro cytotoxicity studies ofchelerythrine-loaded magnetic Fe3O4@O-carboxymethylchitosan nanoparticles. Journal of Experimental Nanoscience. 2013, 10:1-16.

 

21.WeijieYang, Ping Ding, Lei Zhou, Jingang Yu, Xiaoqing Chen, Feipeng Jiao.Preparation of diamine modified mesoporous silica onmulti-walled carbon nanotubes for the adsorption of heavy metals in aqueoussolution. Applied Surface Science.2013, 282: 38– 45

 

22.Dan Sun,Haiyan Wang, Ping Ding, Nan Zhou, Xiaobing Huang, Shuai Tan,Yougen Tang.In-situ synthesis of carbon coated Li2MnSiO4 nanoparticles with high rateperformance. J. Power Sources.2013, 242: 865-871

 

23.PingDing, Gui-Yin Li, Xiao-Qing Chen, Li-Hua Liu. Molecular recognition ofthiol-terminated β-cyclodextrin derivative by using quartz crystalmicrobalance. Instrumentation Science & Technology. 2012, 40: 327-337.

 

24.PingDing, Gui-Yin Li, Xiao-Qing Chen *Zhi-de Zhou. Zinc cross-linked

 

modified chitosan beads: anew matrix for controlled release of theophylline. SpringInternational Conference on ChemicalEngineering. 2012, 342-346.

 

25.PingDing, Guiyin Li, Cuimei Chen, Kelong Huang. Kinetics and Mechanism ofChelatingReaction between Chitosan Derivatives with Ca() Ions.Journal of Coordination Chemistry. 2011, 64: 1333–1343.

 

26.GuiyinLi , Ming Zhong , Zhide Zhou , Yuedan Zhong , Ping Ding, Yong Huang.Novelcarboxymethyl chitosan microspheres for controlled delivery of chelerythrine.Journal of Macromolecular Science - PAC. 2011, 11: 4-11.

 

27.GuiyinLi, Ming Zhong, Zhide Zhoua, Yuedan Zhong, Ping Ding, Yong Huang.Formulationoptimization of chelerythrine loaded O-carboxymethylchitosanmicrospheres usingresponse surface methodology. International Journal of BiologicalMacromolecules. 2011, 49: 970– 978.

 

28.PingDing, Kelong Huang, Hua Yang, Guiyin Li and Yanfei Liu. Equilibrium andkineticsof adsorption of Ca(II) ions onto KCTS and HKCTS. Journal of Central SouthUniversity(Science and Technology). 2010, 17(2), 277-284.

 

29. Guiyin Li, YurenJiang, Kelong Huang, Ping Ding, Jie Chen. Preparation and Properties ofMagnetic Fe3O4-Chitosan Nanoparticles. Journal of Alloysand Compounds. 2008,466:451-456.

 

30. Guiyin Li,Yuren Jiang, Kelong Huang , Ping Ding , Lili Yao. Kinetics of adsorption of saccharomycescerevisiae mandelated dehydrogenase on magnetic Fe3O4-chitosan nanoparticles.Colloids and Surfaces A: Physicochemical and Engineering Aspects 2008,320:11-18.

 

31. Guiyin Li, KelongHuang,Yuren Jiang, Ping Ding, Dongliang Yang. Preparation and Characterizationof Carboxyl Functionalization of Chitosan Derivative Magnetic Nanoparticles.Biochemical Engineering Journal.2008, 40:408-414.

 

32. Guiyin Li, KelongHuang, Yuren Jiang, Dongliang Yang, Ping Ding. Preparation and Characterizationof Saccharomyces cerevisiae AlcoholDehydrogenase Immobilized on Magnetic Nanoparticles. InternationalJournal of Biological Macromolecules.2008,42:405-412.

 

33. Yanfei Liu, KelongHuang, Dongming Peng, Ping Ding, Guiyin Li. Preparation and characterization ofglutaraldehyde cross-linked O-carboxymethylchitosan microspheres for controlleddelivery of pazufloxacin mesilate. International Journal of BiologicalMacromolecules, 2007, 41: 87-93.

 

34. Ping Ding, KelongHuang, Guiying Li, Liu Yanfei. Mechanisms and Kinetics of Chelating Reactionbetween Novel Chitosan Derivatives and Zn () . Journal of HazardousMaterials. 2007, 146: 58-64.

 

35. Ping Ding, KelongHuang, Guiying Li, Wenwen Zeng. Preparation and properties of Modified Chitosanas potential matrix materials for drug sustained-release beads. InternationalJournal of Biological Macromolecules. 2007, 41: 125-131.

 

36. Guiyin Li, KelongHuang, Yuren Jiang, Ping Ding. Production of (R)-mandelic acid by immobilizedcells of Saccharomyces cerevisiae on chitosan carrier. Process Biochemistry2007, 42: 1465-1469.

 

37. Ping Ding, LuiongGuan, Kelong Huang, Lihua Liu. Kinetic Studies on the Formation ofSelf-Assembled Monolayer of Thiol-Terminated β-Cyclodextrin Derivative.International Journal of Applied Chemistry. 2006, 2(1): 73-79.

 

38.Huang W, Liu J, Feng X(通讯作者), Chen H, Zeng L, HuangG, Liu W, Wang L, Jia W, Chen J, Ren C. DLC-1 induces mitochondrial apoptosisand epithelial mesenchymal transition arrest in nasopharyngeal carcinoma bytargeting EGFR/Akt/NF-κB pathway.Med Oncol. 2015 Apr;32(4): 564.

 

39.Feng X, Wang Z, Fillmore R, Xi Y. MiR-200, a new star miRNA inhuman cancer. Cancer Lett. 2014 Mar 28; 344(2):166-73.

 

40.冯湘玲,陈欢,刘卫东,张畅,祝斌,王磊,李敏,周文,姚开泰,任彩萍.甲基转移酶对鼻咽癌细胞中DLC-1 基因表达的影响. 生命科学研究. 20148,18(4):292-298.

 

41.Feng XL, Ren CP, Zhou W, Liu WD, Zeng L, Li GH, Wang L, Li M, ZhuB, Yao KT, Jiang XJ. Promoter Hypermethylation along with LOH, but notMutation, contributes to inactivation of DLC-1 in Nasopharyngeal Carcinoma.Molecular Carcinogen. 2014, 53:858-870.

 

42.Feng XL, Li CLiu WD, Chen Huan, Zhou W, Wang L, Zhu B, Yao KT, Jiang XJ, Ren CP.DLC-1, a candidate tumor suppressor gene, inhibits proliferation, migration andtumorigenicity of human nasopharyngeal carcinoma cell line. Int J Oncol. 2013, 42(6):1973-1984.

 

43.Zhou W, Feng X (并列第一), Ren C, Jiang X, Liu W, Huang W,Liu Z, Li Z, Zeng L,Wang L, Zhu B, ShiJ, Liu J, Zhang C, Liu Y, Yao K. Over-expression of BCAT1, ac-Myc target gene, induces cell proliferation,migration and invasion in nasopharyngeal carcinoma. Mol Cancer. 2013 Jun 8; 12:53.

 

44.Li G, Ren C, Shi J, Huang W, Liu H, Feng X, Liu W, Zhu B, Zhang C,Wang L, Yao K, Jiang X. Identification, expression and subcellular localizationof ESRG. Biochem Biophys Res Commun. 2013 May 24; 435(1):160-4.

 

45.Zhang H, Liu W, Feng X, Wang L, Jiang X, Liu D, Zhang L, Zhu B,Zhou W, Jia W, Li G, Ren C*. Identification of ABCG2+ cells in nasopharyngealcarcinoma cells. Oncol Rep, 2012, 27 (4): 1177-1187.

 

46.Wanggou S, Jiang X*, Li Q, Zhang L, Liu D, Li G, Feng X, Liu W, ZhuB, Huang W,Shi J, Yuan X, Ren C*.HESRG: a novel biomarker for intracranial germinoma andembryonal carcinoma. J NeuroOncol, 106 (2):251-259, 2012.

 

47.张立华,蒋星军,冯湘玲,刘卫东,张树菊,任彩萍*.蛋白酶活化受体1在不同肿瘤中的研究进展.生命科学研究,2012, 16 (3): 277-282.

 

48.Zhang H, Feng X (并列第一), Liu W, Jiang X, Shan W, Huang C,Yi H, Zhu B, Zhou W, Wang L, Liu C, Zhang L, Jia W, Huang W, Li G, Shi J,Wanggou S, Yao K, Ren C. Underlying mechanisms for LTF inactivation and itsfunctional analysis in nasopharyngeal carcinoma cell lines. J Cell Biochem.2011, 112(7):1832-43.

 

49.吴丽莎, 蒋星军, 刘卫东, 周文, 冯湘玲, 李雪华, 祝斌, 王磊, 刘春梅, 姚开泰, 任彩萍. 原位鼻咽癌裸鼠模型血清蛋白质组学的研究. 生命科学研究, 2010, 143):250-256.

 

50.Zhou W, Feng X, Li H, Wang L, Zhu B, Liu W, Zhao M, Yao K, Ren C.Inactivation of LARS2, located at the commonly deleted region 3p21.3, by bothepigenetic and genetic mechanisms in nasopharyngeal carcinoma. Acta BiochimBiophys Sin (Shanghai). 2009, 41(1):54-62.

 

51.Feng XL, Zhou W, Ren CP, Yao KT et al. The DLC-1 -29A/Tpolymorphism is not associated with nasopharyngeal carcinoma risk in Chinesepopulation. Genet Test. 2008, 12(3): 345-9.

 

52.Zhou W, Feng XL (并列第一), Li H, Wang L, Li H, Zhu B, ZhangHJ, Yao KT, Ren CP. Functional evidence for a nasopharyngeal carcinoma relatedgene BCAT1 located at 12p12. Oncol Res. 2007, 16(9): 405-13.

 

53.Zhou L, Feng XL, Shan WJ, Zhou W, Liu WD, Wang L, Zhu B, Yi HM, YaoKT, Ren CP. Epigenetic and genetic alterations of the EDNRB gene innasopharyngeal carcinoma. Oncology. 2007, 72 (5-6): 357-363.

 

54.周文,李虹,冯湘玲,王磊,祝斌,李辉,姚开泰,任彩萍. 利用RNA干扰技术研究PTX1在鼻咽癌中的功能. 中南大学学报(医学版),2007, 32(2): 235-240.

 

55.李虹,韩为农,冯湘玲,周文,张贺军,丁彦青,姚开泰。免疫磁珠法分离鼻咽癌基质的T淋巴细胞。生命科学研究,2006,10(4): 358-361.

 

56.周文,冯湘玲,李虹,王磊,任彩萍,姚开泰。应用小鼠整体原位杂交技术检测MDM2在鼠胚发育不同阶段的表达. 生命科学研究,2006, 10 (2):99-102.

 

57.Zhou L, Jiang W, Ren C, Yin Z, Feng X, Liu W, Tao Q, Yao K.Frequent hypermethylation of RASSF1A and TSLC1, and high viral load ofEpstein-Barr Virus DNA in nasopharyngeal carcinoma and matched tumor-adjacenttissues. Neoplasia. 2005, 7(9): 809-15.

 

58.Liu WD, Feng XL, Ren CP, Shi JL, Yang XY, Zhao M, Zhou L, Lan K,Yao KT. Critical role of Cys168 in noggin protein's biological function. ActaBiochim Biophys Sin (Shanghai). 2005, 37(3):181-5.

 

59.冯湘玲,刘卫东,李虹,王磊,杨旭宇,韩为农,周文,姚开泰。非洲爪蟾GATA-1bGATA-1a差异位点突变后的功能。生物化学与生物物理学报,2003, 35(12): 1105-1110

 

60.李虹,韩为农,冯湘玲,周文,姚开泰。用芯片技术分析鼻咽癌周围的基质细胞基因表达特点。癌症,2003, 22(3): 235-238.

 

61.张玲,蓝轲,冯湘玲,乔贵林,沈新民,石益民,李虹,姚开泰。用鼻咽相对特异性调控区建立N-LMP1转基因小鼠。生物化学与生物物理学报,2003, 35(12):1072-1076.

 

62.冯湘玲,姚开泰。非洲爪蟾GATA-1转录因子与爪蟾发育。生命科学,2002143: 156-158, 162

 

63.周文,冯湘玲,杨旭宇,王磊,姚开泰。DIG标记DNA探针检测noggin在爪蟾胚胎中的表达。生命科学研究。200263)。239242

 

64. 冯湘玲,蓝轲,张玲,周文,史剑凌,刘卫东,姚开泰。一种快速检测启动子特异性的方法。生命科学研究,200154):339-341, 361

 

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