一、基本情况：

姓名：陈立章

职称：二级教授

学位：医学博士

电话：0731-88879752

邮箱：chenliz@csu.edu.cn

部门：中南大学湘雅公共卫生学院流行病与卫生统计学系

研究方向：临床流行病学,传染流行病学,慢性非传染流行病学

二、个人学习与工作经历：

（一）教育经历

1982.9-1987.6：湖南医科大学卫生系本科学习,获医学学士学位

1990.9-1993.6：湖南医科大学卫生系流行病学专业攻读硕士学位，获医学硕士学位

2001.9-2004.6：中南大学湘雅医院内科学（传染病）专业攻读博士学位，获医学博士学位

2007.9-2008.3：渥太华大学访问学者

（二）研究工作经历

1987.7-1990.8：留校任教，任湖南医科大学卫生系教师

1993.7-1994.8：任湖南医科大学研究生处招生办公室科员,1994年晋升讲师

1994.9-1998.10：任湖南医科大学研究生处学位办公室主任兼重点学科建设办公室主任；1998年9月晋升为流行病学副教授

1998.11-2000.11:任湖南医科大学研究生处副处长兼培养办公室主任, 1999年任硕士研究生导师

2000.12-2010.5：任中南大学教务处副处长，2003.9晋升为研究员,2004.6任博士生导师

2010.6-2014.6：任中南大学研究生院培养与管理办公室主任(正处级)；2012.12升正高三级

2014.6-2016.8：任中南大学研究生院招生办公室主任（正处级），2015.9转为教授

2016.9-2019.1：任中南大学本科生院院长(正处级).2016.7任中南大学党委委员。2016.9晋升为二级教授

2019.1-2019.7：任中南大学湘雅医学院党委书记

2019.7-至今： 任中南大学党委常委、副校长

三、研究领域与研究生培养

（一）研究领域：临床流行病学、传染流行病学、慢性非传染流行病学

（二）研究生培养：已招收培养硕士研究生60名、博士研究生30名

四、科研项目（近10年来的代表性研究课题）

1.我国食品中大肠杆菌污染状况调查与评价

国食药监办（2009）184号，2009-2010, 卫生部国家食品药品监督管理局

2.乙肝患者病情判断的分子流行病学研究

编号：2012FJ4133，2012-2013,湖南省科技厅

3.PARD3B、LOC729993、EPHA4、HNT基因多态性与湘西地区侗、汉族2型糖尿病的相关性研究。高等学校博士学科点专项科研基金（博导类）。

编号：20120162110071，2012-2016，教育部

4. 侗族人群2型糖尿病的分子流行病学研究

编号：湘财教指（2013）240号，2013-2015，湖南省财政厅

5. ABCB1、CYP3A5基因多态性与人群血压水平及肾功能关系的研究

编号：2014SK2013，（湘财企2014年4号），2014-2016，湖南省科技厅

6. XXXXXXX纤维制备技术研究（国家863计划）：含铍高聚物先驱体和含铍碳化硅纤维的毒性和安全研究

编号：2014AA7024034，2014-2015，中国人民解放军总装备部

7. 湖南省儿童常见意外伤害调查研究

湘财企指（2016）62号：2016-2017，湖南省财政厅

8. 妇幼健康大型队列及疾病防控研究（湖南省重点研发计划）

编号：2018SK2060，2018-2021，经费：400万，总负责人，湖南省科技厅

9. 妊娠高血压的防治策略研究（湖南省重点研发计划）

编号：2018SK2062，2018-2021，经费：100万，第一负责人，湖南省科技厅

10. 肠道菌群及其代谢物与先兆子痫发生风险的关联及其分子机制研究

编号：81973137，2020.01- 2023.12，经费：55万，国家自然科学基金

五、研究成果：列出近10年来获奖、专著和论文等代表性作品

（一）获奖情况：

1、影响儿童智力发育因素的流行病学研究（陈立章、孙振球、林修寿、谭红专、高建民），1999年湖南省科技进步三等奖，湖南省人民政府

2、“乙型肝炎病毒在肝外组织的感染情况研究”（陈立章，范学工，高建明，刘富强，吴成秋，莫显昆），2012年湖南省自然科学二等奖，湖南省人民政府

3、HIV/AIDS、TB流行特征及基因环境影响机制研究（谭红专、李杏莉、陈立章、陈梦施、秦家碧、陈曦、颜仕鹏），2018年湖南省预防医学科学技术奖二等奖，湖南省预防医学会

4、几种主要慢性传染病的流行特征及防治对策（谭红专、李杏莉、陈立章、陈梦施、秦家碧、陈曦、冯铁建、颜仕鹏），2018年湖南省科技进步二等奖，湖南省人民政府

（二）论文发表情况（*为通讯作者）

1.Zhou Wei, Liu Qian, Yu Yu, Xiao Shuiyuan, Chen Lizhang*, Kaveh Khoshnood, Zheng Shimin.Proxy reliability of the 12-item World Health Organization Disability Assessment Schedule II among adult patients with mental disorders. Quality of Life Research.2020;10.

2.Lijuan Zhao, Lizhang Chen*, Tubao Yang, Tingting Wang, Senmao Zhang, Letao Chen, Ziwei Ye, Liu Luo,Jiabi Qin Birth prevalence of congenital heart disease in China, 1980–2019: a systematic review and meta‑analysis of 617 studies European Journal of Epidemiology, published online:09 June 2020

3.Dexiu Xing , Rong Wu , Lizhang Chen* , Tingting Wang*. Maternal use of antidepressants during pregnancy and risks for adverse perinatal outcomes: a meta-analysis. J Psychosom Res. 2020:8-25, 137:110231.

4.Rong Wu , Tingting Wang*, Runhui Gu, Dexiu Xing, Changxiang Ye , Yan Chen , Xiaoling Liu, Lizhang Chen*. Hypertensive Disorders of Pregnancy and Risk of Cardiovascular Disease-Related Morbidity and Mortality: A Systematic Review and Meta-Analysis. Cardiology. 2020:8-25：1-15.

5.Lizhang Chen, Fuqiang Liu, Xuegong Fan, Jianming Gao, Nengzhi Chen, Tom Wong, Jun Wu, Shi Wu Wen. Detection of hepatitis B surface antigen, hepatitis B core antigen, and hepatitis B virus DNA in parotid tissues.International Journal of Infectious Diseases, 2009,13(1):20-23

6.Lizhang Chen, Chengqiu Wu, Xuegong Fan, Jianming Gao,Hongling Yin,Tom Wang, Jun Wu, Shi Wu Wen. Replication & infectivity of Hepatitis B Virus in HBV related glomerulonephritis.International Journal of Infectious Diseases, 2009, 13(3):394-398

7.Li-Zhang Chen, Wen-Qi Zhou, Shu-Shan Zhao, Zhi-Yu Liu, Shi-Wu Wen. A nested case-control study of maternal-neonatal transmission of hepatitis B virus in a Chinese population. World Journal of Gastroenterology, 2011, 17(31): 3640-3644

8.刘立亚,陈立章*,戴进雄,陈家雄,梁颖,裴庭立,黄永斌.湘西地区侗族2型糖尿病危险因素的病例对照研究.中南大学学报(医学版),2013, 38(10):1057-1064

9.ZhanZhan Li, Jing Xue, Peng Chen, LiZhang Chen*, Shi-Peng Yan, LiYa Liu. Prevalence of nonalcoholic fatty liver disease in mainland of China: a meta-analysis of published studies. Journal of Gastroenterology and Hepatology, 2014，29(1):42-51

10.Zhan-Zhan Li, Ya-Ming Li2, Xian-Yang Lei, Dan Zhang, Li Liu, Si-Yuan Tang, Lizhang Chen*. Prevalence of Suicidal Ideation in Chinese College Students: A Meta-Analysis. PLoS One, 2014,9(10):e104368.

11.Liya LIU, Lizhang CHEN*, Zhanzhan LI, Liang LI, Jian QU, Jing XUE.Association between Gene Polymorphisms of Seven Newly Identified Loci and Type Diabetes and the Correlate Quantitative Traits in Chinese Dong Populations.Iranian J Publ Health, 2014,43(10):1345-1355

12.Zhan-Zhan Li, Lizhang Chen, Tao Zhou, Ze-Min Kuang, Hong Yuan. Relationship between red blood cell distributionwidth and early-stage renal function damage in patients with essential hypertension. Journal of Hypertension, 2014,32(12):2450-2456

13.Xue J, Chen LZ, Li ZZ, Hu YY, Yan SP, Liu LY. MicroRNA-433 inhibits cell proliferation in hepatocellular carcinoma by targeting p21 activated kinase (PAK4). Molecular and Cellular Biochemistry. 2015.399(1-2):77-86

14.S. Yan, L. Chen, W.Wu, Z. Li, Z. Fu, H. Zhang, J. Xue,Y. Hu, J. Mou and C. Fu.Paradoxical immune reconstitution inflammatory syndrome associated with cryptococcal meningitis in China: a 5-year retrospective cohort study.Clinical Microbiology and Infection, 2015; 21(4):311-379

15.Lizhang Chen, Zhanzhan Li, Yanyan Li ,Jing Xue, Peng Chen, Shipeng Yan, Caixiao Jiang, Yingyun Hu, Xing Qiao5. Red Cell Distribution Width and Inappropriateness of Left Ventricular Mass in Patients with Untreated Essential Hypertension.PLOS ONE,2015,10(3):e120300

16.Shipeng Yan，Lizhang Chen*, Wenqiong Wu, Zhongxi Fu, Heng Zhang, Zhanzhan Li, Chenchao Fu, Jingsong Mou, Jing Xue, Yingyun Hu. Early versus Delayed Antiretroviral Therapy for HIV and Tuberculosis Co-Infected Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.PLOS ONE, 2015,10(5):e127645

17.ZhanZhan Li and LiZhang Chen*. Comparison of ultrasound-guided modified Seldinger technique versus blind puncture for peripherally inserted central catheter: a meta-analysis of randomized controlled trials.Critical Care, 2015,19:64

18.Zhanzhan Li, Yanyan Li, Lizhang Chen, Peng Chen, Yingyun Hu. Prevalence of Depression in Patients With Hypertension:A Systematic Review and Meta-Analysis.Medicine(Baltimore),2015,94(31):e1317

19.Cai Xiao Jiang, Zhan Zhan Li, Peng Chen, Li Zhang Chen. Prevalence of Depression Among College-Goers in Mainland China:A Methodical Evaluation and Meta-Analysis.Medicine(Baltimore), 2015,94(50):e2071

20.CaiXiao Jiang, ZhanZhan Li, Peng Chen, LiZhang Chen. The Seroprevalence of Toxoplasma gondii in Chinese Population With Cancer A Systematic Review and Meta-analysis.Medicine(Baltimore), 2015,94(50):e2274 IF=5.723

21.Jing Xue,Wenhang Chen,Lizhang Chen, Laura Gaudet, David Moher,

Mark Walker,Shi Wu Wen.Significant discrepancies were found in pooled estimates of searching with Chinese indexes versus searching with English indexes.Journal of Clinical Epidemiology,2016,70:246-253 IF=4.703

22.Zhanzhan Li, Tao Zhou, Yanyan Li, Peng Chen & Lizhang Chen*.Anemia increases the mortality risk in patients with stroke: A meta-analysis of cohort studies. Scientific Reports, 2016,6:26636

23.Zhan-Zhan Li, Liang-Fang Shen, Yan-Yan Li, Peng Chen, Li-Zhang Chen*.Clinical utility of microRNA-378 as early diagnostic biomarker of human cancers: a meta-analysis of diagnostic test.Oncotarget, 2016,7(36): 58569-58578

24.CaiXiao Jiang,Shujun Liu，Shuxia Liu,ZhanZhan Li, Peng Chen, LiZhang Chen*. Association between the Interleukin-10-1082G/A, −592C/A, 819C/T Gene Polymorphism and HIV-1 Susceptibility: A Meta-analysis.AIDS Research and Human Retroviruses,2017,33(1):61-67 (SCI)

25.Zhanzhan Li, Peng Chen, Tao Zhou, Xiaofang Chen，Lizhang Chen *.Association between CYP3A5 genotypes with hypertension in Chinese Han population: A casecontrol study.Clinical and Experimental Hypertension.2017, 39(3): 235–240

26.Zhi Yin, Jin Zou, Qiongxuan Li, Lizhang Chen*. Diagnostic value of FIB-4 for liver fibrosis in patients with hepatitis B: a meta-analysis of diagnostic test.Oncotarget. 2017,1: 1-10

27.Wang T, Liu K, Li Z, Xu Y, Liu Y, Shi W, Chen L*. Prevalence of attention deficit/hyperactivity disorder among children and adolescents in China: a systematic review and meta-analysis. BMC Psychiatry, 2017, 17(1): 32

28.Huiqing Wang，Tingting Wang，Wenpei Shi, Yuan Liu, Lizhang Chen* and Zhanzhan Li*.Comprehensive analysis on diagnostic value of circulating miRNAs for patients with ovarian cancer.Oncotarget, 2017, 8(39): 66620-66628

29.Tingting Wang, Yuan Liu, Zhanzhan Li, Kaihua Liu, Yang Xu, Wenpei Shi,

Lizhang Chen*. Prevalence of intimate partner violence (IPV) during pregnancy in China: A systematic review and meta-analysis. PLOS ONE. 2017,10:1-17

30.Li Q, Yin Z, Wang T, Chen L*, Li Z*. Gemcitabine and cisplatin regimen facilitates prognosis of advanced nasopharyngeal carcinoma. Cancer Med. 2018, 7(7): 2985-2992

31.Wang T, Fu H, Kaminga AC, Li Z, Guo G, Chen L*, Li Q*. Prevalence of depression or depressive symptoms among people living with HIV/AIDS in China: a systematic review and meta-analysis. BMC Psychiatry 2018, 18(1):160

32.Liu Z, Wang T, Liu Y, Wang A, Xie D, Kong F, Xiong L, Chen L*, Wang H*. Evaluating the progress to eliminate mother-to-child transmission (MTCT) of syphilis in Hunan Province, China: A study based on a health service delivery model.

Plos one, 2018, 13(9): e0203565.

33.Wei Zhou, Yu Yu, Mei Yang, Lizhang Chen and Shuiyuan Xiao*. Policy development and challenges of global mental health: a systematic review of published studies of national-level mental health policies. BMC Psychiatry, 2018,18:138

34.Wei Zhou, Yu Yu, Xinyi Zhao, Shuiyuan Xiao* and Lizhang Chen*. Evaluating China’s mental health policy on local-level promotion and implementation: a case study of Liuyang Municipality. BMC Public Health, 2019: 19--24

35.Shiyu Cao , Fuqiang Liu, Tingting Wang , Yaqing Tan ,Shujun Liu , Yuan Liu , Lidong Gao ,* Lizhang Chen *. New patterns emerge after a sustained increase in

the incidence of hepatitis C virus infection from 2004 to 2017: a joinpoint regression analysis. Public health, 2019,170:49-56

六、教学：承担的主要课程、教材编写等

（一）承担的主要课程：

1.流行病学

2.循证医学

3.临床流行病学

（二）教材编写：

1.主编、《循证医学》、高等教育出版社、2015

2.主编、《管理流行病学》、中南大学出版社、2013

3.主编、《循证医学与实践》、中南大学出版社、2012年

4.副主编、《临床流行病学》、中南大学出版社、2010年

5.副主编、《临床流行病学》、中南大学出版社、2004年

6.参编、《社区医学》、人民卫生出版社、2001年

七、社会兼职：学会、杂志编委等（各限列5项）

1.临床流行病学湖南省重点实验室主任

2.湖南省医学科教学会副会长

3.中国学位与研究生教育学会医药科工作委员会委员

4.教育部高等学校实验室建设与实验教学指导委员会委员

5.中国高等教育学会理事